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Human CellExp R spondin-1, human recombinant |
| 中文名称 |
【R spondin 1】人源细胞表达的重组人R spondin-1（10 ug） |
| 供应商 |
BioVision |
产品货号 |
7482-10 |
| 产品报价 |
客服1： 客服2： |
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购买方式
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银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系010-52406250. |
| 产品新闻 |
| 微信号：AD-Bio |
订阅号： Bio-888 |
技术微信:hugasis |
销售微：ex-2008 |
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| 背景资料 |
R-spondin-1, also known as Roof plate-specific Spondin 1 (RSPO1) and cysteine rich and single thrombospondin domain containing protein 3 (Cristin 3), is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. All R spondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteine rich furin like domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furin like domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus. Potential isoforms of 200 and 236 aa have an alternate, shorter N-terminus or are missing aa 146-208, respectively. R-Spondin-1 is expressed in early development at the roof plate boundary and is thought to contribute to dorsal neural tube development. Human RSPO1 disruption results in a recessive syndrome characterized by XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. It has been shown that the complete female-to-male sex reversal is due to the absence of the testis-determining gene, SRY. R-Spondin-1 regulates Wnt/β-catenin by competing with the Wnt antagonist DKK1 for binding to the Wnt co receptors, Kremen and LRP6, reducing their DKK1 mediated internalization. Reports differ on whether R-spondin 1 binds LRP6 directly. |
| 产品描述 |
该人源细胞表达的重组人R spondin-1产品为冻干形式.具体样式见英文说明：Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
| 来源宿主 |
提供的【R spondin 1】人源细胞表达的重组人R spondin-1产品的来源为人胚肾HEK293细胞重组表达重组表达. |
| 序列 |
人源细胞表达的重组人R spondin-1蛋白产品，又称RSPO1, RSPO-1, CRISTIN3, CRISTIN-3, FLJ409
06, RP11-566C13.1, RSPO, R-spondin-1, Rspondin-1, Rspondin1, Rspondin.
其对应NCBI基因号为284654，对应Accession号为Q2MKA7.
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| 溶解建议 |
人源细胞表达的重组人R spondin-1产品请按照说明书建议进行溶解操作：Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| 保存建议 |
在您收到发出的【R spondin 1】人源细胞表达的重组人R spondin-1产品后，建议将其置于-20°C保存. |
| 产品说明书 |
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