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Human CellExp GCSFR /CD114, human recombinant |
中文名称 |
【GCSFR】人源细胞表达的重组人GCSFR/CD114(20 ug) |
供应商 |
BioVision |
产品货号 |
7480-20 |
产品报价 |
客服1: 客服2: |
购买方式
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银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系010-52406250. |
产品新闻 |
微信号:AD-Bio |
订阅号: Bio-888 |
技术微信:hugasis |
销售微:ex-2008 |
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背景资料 |
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I?II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia. |
产品描述 |
该人源细胞表达的重组人GCSFR/CD114产品为冻干形式.具体样式见英文说明:Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
来源宿主 |
提供的【GCSFR】人源细胞表达的重组人GCSFR/CD114产品的来源为人胚肾HEK293细胞重组表达重组表达. |
序列 |
人源细胞表达的重组人GCSFR/CD114蛋白产品,又称CSF3R, CD114, GCSFR.其对应NCBI基因号为1441,对应Acce
ssion号为Q99062.
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溶解建议 |
人源细胞表达的重组人GCSFR/CD114产品请按照说明书建议进行溶解操作:Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
保存建议 |
在您收到发出的【GCSFR】人源细胞表达的重组人GCSFR/CD114产品后,建议将其置于-20°C保存. |
产品说明书 |

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