GW 9662 货号：F-70785-10
GW 9662, 2-chloro-5-nitrobenzanilide
背景资料：The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.
产品描述：The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR.gamma. agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPAR.gamma. agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPAR.gamma.-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE, which is another reported PPAR.gamma. antagonist.
保存建议：-20℃保存，产品有效期730天
定购信息：
| 产品名称 |
规格 |
操作手册 |
货号 |
询价 |
| GW 9662 |
10 mg |
PDF |
F-70785-10 |
 |
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